崔 博

一、个人简介

崔博，博士，研究员，现为军事科学院军事医学研究院环境医学与作业医学研究所研究室主任。兼任科技部、天津市科技专家库成员，国家自然科学基金通讯评委，中国计量测试学会声学计量测试分会委员，天津预防医学会劳动卫生与职业病分会常务委员，天津市声学会理事，解放军预防医学杂志编委，Physiol Behav, Int J Exp Pathol, Diabetes Obes Metab, Neuroscience, J Int Med Res和中国应用生理学杂志、天津医药、中华脑科疾病与康复杂志等刊物审稿专家。主持国家及天津市自然科学基金、全军重点项目等课题10余项，经费600余万元。发表论文60余篇，其中第一或通讯作者SCI论文18篇（总影响因子73，被引360余次）；获授权国家专利等各类知识产权11项，参编出版专著3部；目前带教研究生9人。邮箱：iamcuib@sina.com, tjcuibo@126.com。

二、研究方向

基础研究方面主要聚焦环境物理危害因素及其损伤防护，开展环境与健康风险评价、效应机制研究；应用研究方面主要开展环境物理危害因素控制、损伤效应监测预警以及防护保障应用技术研发。

三、代表性科研项目

1、长期噪声暴露与典型内环境风险因子协同对AD的促发效应及其启动机制研究（81673136）, 国家自然科学基金面上项目，第一位，2017.01-2020.12，65万元。

2、长期噪声暴露对阿尔茨海默病的促发效应及其启动机制研究, 天津市自然科学基金重点项目（17JCZDJC34900），2017.04-2020.03，第一位，20万元。

3、XXX（保密课题），中央军委后勤保障部， 2021.06-2024.12，第一位，423万元。

4、XXX（保密课题），中央军委科技委， 2019.06-2021.10，第一位，327万元。

5、XXX（保密课题），中央军委后勤保障部， 2020.01-2022.12，第一位，50万元。

四、代表性论文

1. Chi Huimin, Cao Wa, Zhang Ming, Su Donghong, Yang Honglian, Li Zhe, Li Chao, She Xiaojun, Wang Kun, Gao Xiujie, Ma Kefeng, Zheng Pengfang, Li Xiaofang, Cui Bo(通讯作者). Environmental noise stress disturbs commensal microbiota homeostasis and induces oxi-inflammmation and AD-like neuropathology through epithelial barrier disruption in the EOAD mouse model. Journal of Neuroinflammation 2021, 18: 9.

2. Cui Bo (共同第一/通讯作者), Su Donghong, Li Wenlong, She Xiaojun, Zhang Ming, Wang Rui, Zhai Qingfeng. Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease. Journal of Neuroinflammation,2018,15:190.

3. Ma Kefeng, Zhang Anran, She Xiaojun, Yang Honglian, Wang Kun, Zhu Yingwen, Gao Xiujie, Cui Bo(共同通讯作者). Disruption of glutamate release and uptake-related protein expression after noise-induced synaptopathy in the cochlea.Frontiers in Cell and Developmental Biology, section Molecular and Cellular Pathology, 2021, 9: 720902.

4. Chi Huimin, Zhai Qiingfeng, Zhang Ming, Su Donghong, Cao Wa, Li Wenlong, She Xiaojun , Yang Honglian, Wang Kun, Gao Xiujie, Ma Kefeng, Cui Bo(共同通讯作者), Qiu Yugang. APP/PS1 Gene–Environment Noise Interaction Aggravates AD-like Neuropathology in Hippocampus Via Activation of the VDAC1 Positive Feedback Loop. Current Alzheimer Research, 2021, 18(1):14-24.

5.Li Wenlong, Su Donghong, Zhai Qingfeng,Chi Huimin, She Xiaojun, Gao Xiujie, Wang Kun, Yang Honglian, Wang Rui,Cui Bo(通讯作者) . Proteomes analysis reveals the involvement of autophagy in AD-like neuropathology induced by noise exposure and ApoE4. Environmental Research, 2019, 108537.

6. Yang Honglian, Liu Huanliang, Zhang Wei, She Xiaojun, Gao Xiujie, Ma Kefeng, Wang Kun, Cui Bo(共同通讯作者), Fang Yanjun, Xi Zhuge. Thyroid-disrupting effects and mechanism of thiazole-Zn-induced thyroidcell hypertrophy and hyperplasia in male Sprague-Dawley rats. Ecotoxicology and Environmental Safety, 2020, 196: 110544.

7. Su Donghong , Li Wenlong , Chi Huimin , Yang Honglian, She Xiaojun, Wang Kun, Gao Xiujie, Ma Kefeng, Zhang Ming, Cui Bo(共同通讯作者). Transcriptome analysis of the hippocampus in environmental noise-exposed SAMP8 mice reveals regulatory pathways associated with Alzheimer’s disease neuropathology. Environmental Health and Preventive Medicine, 2020, 25:3.

8.Gai Zhihui, Su Donghong, Wang Yawen, Li Wenlong, Cui Bo(共同通讯作者), Li Kang, She Xiaojun Wang Rui. Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer’s disease-like tau hyperphosphorylation. Environmental Health and Preventive Medicine, 2017, 22:79.

9. Cui Bo(第一/通讯作者), Zhu Lixing, She Xiaojun, Wu Mingquan, Ma Qiang, Wang Tianhui, Zhang Na, Xu Chuanxiang, Chen Xuewei, An Gaihong, Liu Hongtao. Chronic Noise Exposure Causes Persistence of Tau Hyperphosphorylation and Formation of NFT Tau in the Rat Hippocampus and Prefrontal Cortex. Experimental Neurology, 2012, 238:122-129.

10. Cui Bo(第一/通讯作者), Wu Mingquan, She Xiaojun, Liu Hongtao. Impulse noise exposure in rats causes cognitive deficits and changes in hippocampal neurotransmitter signaling and tau phosphorylation. Brain Research, 2012,1427: 35-43.