王 团 伟

一、个人简介

王团伟，博士，副教授，硕士研究生导师，毕业于复旦大学公共卫生学院。承担本科生、研究生《预防医学》、《职业卫生与职业医学》、《环境卫生学》等课程的教学与实验，以第一/通讯作者发表SCI论文10篇，中国毒理学会毒理学教育专业委员会委员、山东省公共卫生学会卫生毒理分会委员，山东预防医学会卫生毒理分会委员，《工业卫生与职业病》、《环境卫生学杂志》、《毒理学杂志》期刊编委。目前指导硕士研究生5名，邮箱wangtuanwei@sdsmu.edu.cn。

二、研究方向

职业/环境化学物毒理机制与生物标志物。研究领域涉及重金属、苯、农药、新型有机污染物，采用人群现场结合细胞、动物实验开展职业/环境化学物的遗传毒性、生殖毒性及其分子机制，聚焦于DNA甲基化、非编码RNA、组蛋白修饰等表观遗传调控机制。应用全基因组学、表观遗传组学、转录组学、蛋白质组学等多组学数据与人群健康效应相关联，鉴定生物标志物，并结合细胞、动物实验进行生物学功能验证，筛选关键分子通路和靶标，旨在为人群生物监测和早期筛查提供策略。

三、代表性科研项目

1.DNA甲基化在职业铅接触致遗传损伤中的调控机制（ZR2022QH180），山东省自然科学基金青年基金，2023.01.01-2025.12.31，第一位，15万；

2.抗生素抗性基因（AMRs）在人群中的暴露特征及传播规律研究（LH2022GG07），国家食品安全风险评估中心2022年度科研联合攻关计划项目，2022.7-2025.6，第一位，10万；

3.DNMT1调控DNA损伤应答基因甲基化在环境铅暴露致遗传损伤中的作用机制研究（2022YX040），2022年潍坊市科技发展计划项目（医学类），2022.11-2025.12，第一位，1万；

4.DNA甲基化及其关联基因多态性在职业铅暴露致遗传损伤中的调控机制（2021BKQ），潍坊医学院A类博士科研启动基金，2022.01-2026.12，第一位，72万；

四、代表性论文

1. Zhiyuan Han, Shiyang Gong, Yuting Tu, Chunyan Lang, Jiachun Tang, Tuanwei Wang^*, Zhao-Lin Xia. The Relationships Between Blood Pb Levels and Blood Pressure Among Lead-Exposed Workers in China: A Repeated-Measure Study. Journal of Occupational and Environmental Medicine, 2023Dec1;65(12):e759-e763.doi:10.1097/JOM.0000000000002974.

2. Tuanwei Wang^#, Yu Meng^#, Yuting Tu, Guanghui Zhang, Kan Wang, Shiyang Gong, Yunxia Zhang, Tongshuai Wang, Anqi Li, David C. Christiani, William Au, Zhao-lin Xia^*. Associations between DNA methylation and genotoxicity among lead-exposed workers in China. Environmental Pollution2022, 316:120528. doi:10.1016/j.envpol.2022.120528.

3. TuanweiWang^#, Yuting Tu^#, Guanghui Zhang^#, Shiyang Gong^#, Kan Wang^#, Yunxia Zhang, Yu Meng, Tongshuai Wang, Anqi Li, David C. Christiani, William Au, Yiliang Zhu^*, Zhao-lin Xia^*. Development of a benchmark dose for lead-exposure based on its induction of micronuclei, telomere length changes and hematological toxicity.EnvironmentInternational2020,145:106129.doi:10.1016/j.envint.2020.106129.

4. Tuanwei Wang^#, Yuting Tu^#, Kan Wang, Shiyang Gong, Guanghui Zhang, Yunxia Zhang, Yu Meng, Tongshuai Wang, Anqi Li, Junpeng Cui, Huan Liu, Weifeng Tang, Jing Xi, Yiyi Cao, Yang Luan, David C. Christiani, William Au, Zhao-lin Xia^*. Associations of blood lead levels with multiple genotoxic biomarkers among workers in China: A population-based study. EnvironmentalPollution2020,273:116181. doi:10.1016/j.envpol.2020.116181.

5. Yu Meng^#, Kan Wang^#, Tuanwei Wang, Yuting Tu, Shiyang Gong, Yunxia Zhang, Guanghui Zhang, William Au, David C. Christiani, Zhao-lin Xia^*. Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity. EnvironmentalInternational2021,151:106448. doi:10.1016/j.envint.2021.106448.

6. Yiyi Cao^#, Tuanwei Wang^#, Jing Xi, Guanghui Zhang, Tongshuai Wang, Weiying Liu, Xinyue You, Xinyu Zhang, Zhao-lin Xia^*, Yang Luan^*. PIG-A gene mutation as a genotoxicity biomarker in human population studies: An investigation in lead-exposed workers. Environmental and molecular mutagenesis 2020, 61(6):611-621.

7. Kan Wang^#, Tuanwei Wang^#, Jie Xu^#, Yiliang Zhu, Le Jian, William Au, Zhao-lin Xia^*. Determination of benchmark dose based on adduct and micronucleus formations in formaldehyde-exposed workers. Int J Hyg Environ Health 2019, 222(5):738-743.

8. Kan Wang^#, Yu Meng^#, Tuanwei Wang^#, Yuting Tu^#, Shiyang Gong, Guanghui Zhang, William Au, Zhao-lin Xia^*. Global and gene-specific promoter methylation, and micronuclei induction in lead-exposed workers: A cross-sectional study. Environ Mol Mutagen 2021,62(7):428-434.

9. Tuanwei Wang^#, Hui Zhang^#, Lei Li, Wenjuan Zhang^*, Qi Wang, Wei Wang^*. Plasma cholinesterase activity is influenced by interactive effect between Omethoate exposure and CYP2E1 polymorphisms. J Environ Sci Health B2021,56(5):477-482.

10. Tuanwei Wang^#, Sihua Wang^#, Xiaoran Duan^#, Xiaolei Feng^#, Pengpeng Wang, Wu Yao, Yongjun Wu, Feifei Feng, Songcheng Yu, Yiming Wu, Wei Wang^*. Application of created restriction site PCR-RFLP to identify POT1 gene polymorphism. Biochemistry (Moscow)2016, 81(6):624-627.