徐 萍

一、个人简介

徐萍，博士，三级教授，现为枣庄学院科研团队负责人。河南省高校青年骨干教师、国家自然科学基金委一审评审专家、第九批河南省重点学科-药剂学学科带头人、教育部学位中心评审专家、山东省省级高层次人才、枣庄学院科研团队负责人。主要研究方向为抗辐射药物作用的分子机制，目前主持国家自然科学基金3项，省部级和市厅级课题3项。以第一作者和通讯作者发表SCI论文17篇，申请专利7项，其中授权3项（第一位2项，第二位1项）。获得河南省医学科学进步二等奖(第一位)1项，河南省教育厅科技成果奖3项（第一，第一，第二），河南省自然科学优秀学术论文奖（第一）。目前带教研究生2人。导师邮箱：13273730271@163.com

二、研究方向

研究方向和研究领域的描述主要方向为抗辐射药物作用的分子机制，课题主要涉及药物辐射防护作用靶点的发现、阅读器蛋白依赖的m6A甲基化修饰lncRNA介导辐射损伤的机制、lncRNA-miRNA、miRNA-mRNA相互作用。

三、代表性科研项目

1.  “miR-147a靶向调控PDPK1”在曲克芦丁干预电离辐射损伤中的机制研究（81773358），国家自然科学基金面上项目，2018.01.01-2021.12.31，第一位，54万

2. 远志皂苷B通过NF-κB/Caspase-3干预胸腺电离辐射损伤的机制研究（11705158），国家自然科学基金青年项目，2018.01.01-2020.12.31，第一位，31.2万

3. 基于PARP-1靶分子研究刺梨黄酮干预胸腺细胞辐射损伤的机制（U1504824），国家自然科学基金联合项目，2016.01-2018.12，第一位，30万

4. 基于“绿色”防护的刺梨黄酮抗辐射损伤作用机制研究(142102310302), 河南省科技厅重点科技攻关项目，2014.01-2016.12. 第一位，5万

5. 刺梨黄酮对胸腺细胞辐射损伤干预的分子机制（2014GGJS-098），河南省高等学校青年骨干教师计划，2015.01-2017.12，第一位，4万

四、代表性论文

1、Nan Zhang, Gui-Yuan Song, Qing-Hua Yu, Xin-Ming Fan, Wen-Shuo Zhang, Yong-Jian Hu, Tian-Zhu Chao, Yao-Yao Wu, Shu-Yan Duan, Fei Wang,Rui-Peng Du, Ping Xu*（通讯作者）. Evaluation of the lncRNA-miRNA-mRNA ceRNA network in lungs of miR-147 −/− mice, Front Pharmacol., 2024,1335

-374

2、Li WH, Wang F, Song GY, Yu QH, Du RP, Xu P*（通讯作者）. PARP-1: a critical regulator in radioprotection and radiotherapy-mechanisms, challenges, and therapeutic opportunities, Front Pharmacol., 2023,14:1198948.

3、Nan Zhang, Gui-yuan Song, Yong-jian Hu, Xia Wang, Tian-zhu Chao, Yao-yao Wu, Ping Xu*（通讯作者）. Analysis of lncRNA-miRNA-mRNA Expression in the Troxerutin-Mediated Prevention of Radiation-Induced Lung Injury in Mice, J Inflamm Res., 2023,16:2387-2399.

4、Gui-yuan Song, Yong-jian Hu, Nan Zhang, Fei Wang, Tian-

zhu Chao, Yao-yao Wu, Yu-feng Li, Ping Xu*（通讯作者）. Construction and validation of a competing endogenous RNA network in the thymus of miR-147-/- mice，international immunopharmacology，2023,117:109896

5、Yong-jian Hu, Gui-yuan Song, Fan Zhang, Nan Zhang, Fei

Wang, Jing-long Wang, Xia Wang, Tao-yang Wang, Yu-feng Li, Yi-di Yan, Wen-tao Dou, Chen-yi Cheng, Ping Xu*（通讯作者）. Activation of long-noncoding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 by troxerutin，iScience, 2023,26(2):105932.

6、Tao-yang Wang, Yong-jianHu, Xia Wang, Yu-fengLi, Fan

Zhang, Yi-di Yan, Wen-tao Dou, Chen-yi Cheng, Ping Xu*. Targeting p65 to inhibit Cas3 transcription by Onjisaponin B for radiation damage therapy in p65+/- mice，Phytomedicine，2022,104:154317.

7、Ping Xu*, Xinhua Cai, Wenbo Zhang, Yana Li,Peiyong Qiu. Flavonoids of Rosa roxburghii Tratt exhibit radioprotection and anti-apoptosis properties via the Bcl-2(Ca2+)/Caspase-3/PARP-1pathway, Apoptosis, 2016, 21(10):1125-1143.

8、Ping Xu*（通讯作者）, Wen-Bo Zhang, Xin-Hua Cai, Pei-Yong Qiu, Ming-Hua Hao, Dan-Dan Lu. Activating AKT to inhibit JNK by troxerutin antagonizes radiation-induced PTEN activation. Eur J Pharmacol, 2017,795(15) :66–74.      

9、Ping Xu, Xingxia Liu, Xiwen Xiong, Wenbo Zhang, Xinhua Cai, Peiyong Qiu, Minghua Hao, Lijuan Wang, Dandan Lu, Xiuhua Zhang, Wancai Yang. Flavonoids of Rosa roxburghiiTrattexhibit anti-apoptosis properties by regulatingPARP-1/AIF, J Cell Biochem, 2017,118: 3943–3952.   2.959

10、Li-Juan Wang, Na-na Li, Sai-Juan Xu, Fan Zhang, Ming-Hua Hao, Xian-jun Yang, Xin-Hua Cai,Pei-Yong Qiu, Hong-long Ji, Ping Xu*（通讯作者）.A new and important relationship between miRNA-147a and PDPK1 in radiotherapy, J Cell Biochem, 2018,119:3519–3527. IF:3.448  

11、Sai Juan Xu, Fan Zhang, Li Juan Wang, Ming Hua Hao, Xian jun Yang, Na na Li, Hong long Ji, Ping Xu*（通讯作者）.Flavonoids of Rosa roxburghii Tratt offers protection against radiation induced apoptosis and inflammation in mouse thymus, Apoptosis, 2018, 23（9-10）:470–483.

12、Sai-Juan Xu, Xia Wang，Tao-yang Wang, Zheng-zhan Lin，Yong-jian Hu， Zhong-lin Huang， Xian-jun Yang, Ping Xu*（通讯作者）.Flavonoids from Rosa roxburghii Tratt prevent reactive oxygen species-mediated DNA damage in thymus cells both combined with and without PARP-1 expression after exposure to radiation in vivo,  aging, 2020,12（16）:16368-16389.    

13、Xu Ping, Jia Junqing, Jia Junfeng and Jiang Enjin, Radioprotective effects of troxerutin against gamma irradiation in mice live, Inter J Radiat Biol, 2012,88(8):607–612.