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徐 萍
一、个人简介
徐萍,博士,教授,现为枣庄学院科研团队负责人。河南省高校青年骨干教师、国家自然科学基金委一审评审专家、第九批河南省重点学科-药剂学学科带头人、教育部学位中心评审专家、山东省省级高层次人才、枣庄学院科研团队负责人。主要研究方向为抗辐射药物作用的分子机制,目前主持国家自然科学基金3项,省部级和市厅级课题3项。以第一作者和通讯作者发表SCI论文17篇,申请专利7项,其中授权3项(第一位2项,第二位1项)。获得河南省医学科学进步二等奖(第一位)1项,河南省教育厅科技成果奖3项(第一,第一,第二),河南省自然科学优秀学术论文奖(第一)。目前带教研究生2人。
二、研究方向
研究方向和研究领域的描述主要方向为抗辐射药物作用的分子机制,课题主要涉及药物辐射防护作用靶点的发现、lncRNA-miRNA、miRNA-mRNA相互作用。
三、代表性科研项目
“miR-147a靶向调控PDPK1”在曲克芦丁干预电离辐射损伤中的机制研究(81773358),国家自然科学基金面上项目,2018.01.01-2021.12.31,第一位,54万
远志皂苷B通过NF-κB/Caspase-3干预胸腺电离辐射损伤的机制研究(11705158),国家自然科学基金青年项目,2018.01.01-2020.12.31,第一位,31.2万
基于PARP-1靶分子研究刺梨黄酮干预胸腺细胞辐射损伤的机制(U1504824),国家自然科学基金联合项目,2016.01-2018.12,第一位,30万
基于“绿色”防护的刺梨黄酮抗辐射损伤作用机制研究(142102310302), 河南省科技厅重点科技攻关项目,2014.01-2016.12. 第一位,5万
刺梨黄酮对胸腺细胞辐射损伤干预的分子机制(2014GGJS-098),河南省高等学校青年骨干教师计划,2015.01-2017.12,第一位,4万
四、代表性论文
1、Gui-yuan Song, Yong-jian Hu, Nan Zhang, Fei Wang, Tian-
zhu Chao, Yao-yao Wu, Yu-feng Li, Ping Xu*. Construction and validation of a competing endogenous RNA network in the thymus of miR-147-/- mice,international immunopharmacology.2023;117: 109896
2、Yong-jian Hu, Gui-yuan Song, Fan Zhang, Nan Zhang, Fei
Wang, Jing-long Wang, Xia Wang, Tao-yang Wang, Yu-feng Li, Yi-di Yan, Wen-tao Dou, Chen-yi Cheng, Ping Xu*. Activation of long-noncoding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 by troxerutin,iScience, 2023;26(2):105932.
3、Tao-yang Wang, Yong-jianHu, Xia Wang, Yu-fengLi, Fan
Zhang, Yi-di Yan, Wen-tao Dou, Chen-yi Cheng, Ping Xu*. Targeting p65 to inhibit Cas3 transcription by Onjisaponin B for radiation damage therapy in p65+/- mice,Phytomedicine,2022 Sep;104:154317. doi: 10.1016/j.phymed.2022.154317. IF 6.656 2022.07.04
4、Ping Xu*, Xinhua Cai, Wenbo Zhang, Yana Li,Peiyong Qiu. Flavonoids of Rosa roxburghii Tratt exhibit radioprotection and anti-apoptosis properties via the Bcl-2(Ca2+)/Caspase-3/PARP-1pathway, Apoptosis, 2016, 21(10):1125-1143.
5、Ping Xu*, Wen-Bo Zhang, Xin-Hua Cai, Pei-Yong Qiu, Ming-Hua Hao, Dan-Dan Lu. Activating AKT to inhibit JNK by troxerutin antagonizes radiation-induced PTEN activation. Eur J Pharmacol, 2017,795(15) :66–74.
6、Ping Xu, Xingxia Liu, Xiwen Xiong, Wenbo Zhang, Xinhua Cai, Peiyong Qiu, Minghua Hao, Lijuan Wang, Dandan Lu, Xiuhua Zhang, Wancai Yang. Flavonoids of Rosa roxburghiiTrattexhibit anti-apoptosis properties by regulatingPARP-1/AIF, J Cell Biochem, 2017,118: 3943–3952. 2.959
7、Li-Juan Wang, Na-na Li, Sai-Juan Xu, Fan Zhang, Ming-Hua Hao, Xian-jun Yang, Xin-Hua Cai,Pei-Yong Qiu, Hong-long Ji, Ping Xu*(通讯作者).A new and important relationship between miRNA-147a and PDPK1 in radiotherapy, J Cell Biochem, 2018,119:3519–3527. IF:3.448
8、Sai Juan Xu, Fan Zhang, Li Juan Wang, Ming Hua Hao, Xian jun Yang, Na na Li, Hong long Ji, Ping Xu*(通讯作者).Flavonoids of Rosa roxburghii Tratt offers protection against radiation induced apoptosis and inflammation in mouse thymus, Apoptosis, 2018, 23(9-10):470–483.
9、Sai-Juan Xu, Xia Wang,Tao-yang Wang, Zheng-zhan Lin,Yong-jian Hu, Zhong-lin Huang, Xian-jun Yang, Ping Xu*(通讯作者).Flavonoids from Rosa roxburghii Tratt prevent reactive oxygen species-mediated DNA damage in thymus cells both combined with and without PARP-1 expression after exposure to radiation in vivo, aging, 2020,12(16):16368-16389.
10、Xu Ping, Jia Junqing, Jia Junfeng and Jiang Enjin, Radioprotective effects of troxerutin against gamma irradiation in mice live, Inter J Radiat Biol, 2012,88(8):607–612.