邵 波

一、个人简介

邵波，博士，副教授，现为毒理学教研室秘书。山东预防医学会理事，山东预防医学会环境卫生分会委员，山东省公共卫生与消毒感控学会委员。主要承担《毒理学基础》及《食品毒理学》的教学工作，完成校级教研项目一项。近五年以第一作者或通讯作者发表中科院二区及以上SCI论文5篇，合作发表较高水平SCI论文20余篇，累计影响因子140分左右。主持国家自然科学基金青年基金1项，山东省自然科学基金1项，国家重点实验室开放基金1项。获山东省预防医学科学技术奖二等奖，获“山东省优秀预防医学科技工作者”称号。目前带教研究生2

。导师邮箱shaobo@mail.jnmc.edu.cn。

二、研究方向

新型化合物诱导或抑制铁死亡的分子机制研究。近期提出了一类新型的铁死亡分子机制，该机制对于铁死亡相关疾病的治疗具有重要意义。

三、代表性科研项目

1、五氯酚的两类氢醌代谢产物与铜-邻菲罗啉对DNA产生相反复合效应的分子机制研究（22006050），国家自然科学基金青年基金，2021.01-2023.12，第一位，24万元。

2、卤代儿茶酚抑制铜-邻菲罗啉诱导DNA损伤的分子机理研究（ZR2017LB029），山东省自然科学基金，2017.08-2019.12，第一位，5万元。

3、铜离子介导的2,6-二溴氢醌损伤DNA的分子机理研究（KF2016-18），环境化学与生态毒理学国家重点实验室开放基金，2017.01-2018.12，第一位，5万元。

四、代表性论文

1、Miao Qin^#, Bo Shao^{#, **}（通讯作者）, Li Lin, Zhao-Qiang Zhang, Zhi-Guo Sheng, Li Qin, Jie Shao, Ben-Zhan Zhu^*（通讯作者）, Molecular mechanism of the unusual biphasic effects of the natural compound hinokitiol on iron-induced cellular DNA damage, Free Radical Biology and Medicine, 2023, 194: 163-171.

2、Bo Shao, Li Mao, Miao Tang, Zhu-Ying Yan, Jie Shao, Chun-Hua Huang, Zhi-Guo Sheng and Ben-Zhan Zhu^*（通讯作者）, Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity, Antioxidants, 2021, 10(5). 798.

3、Bo Shao, Li Mao, Jie Shao, Chun-Hua Huang, Li Qin, Rong Huang, Zhi-Guo Sheng, Dong Cao, Zhao-Qiang Zhang, Li Lin, Chun-Zhi Zhang, Ben-Zhan Zhu^*（通讯作者）, Mechanism of synergistic DNA damage induced by caffeic acid phenethyl ester (CAPE) and Cu(II): Competitive binding between CAPE and DNA with Cu(II)/Cu(I), Free Radical Biology and Medicine, 2020, 159. 107-118.

4、Bo Shao（通讯作者）, Mei-Xia Wang, An-Ran Chen, Chun-Zhi Zhang, Li Lin, Zhao-Qiang Zhang, An-Lan Chen, Protective effect of caffeic acid phenethyl ester against imidacloprid-induced hepatotoxicity by attenuating oxidative stress, endoplasmic reticulum stress, inflammation and apoptosis, Pesticide Biochemistry and Physiology, 2020, 164. 122-129.

5、Bo Shao, Li Mao, Na Qu, Ya-Fen Wang, Hui-Ying Gao, Feng Li, Li Qin, Jie Shao, ChunHua Huang, Dan Xu, Lin-Na Xie, Chen Shen, Xiang Zhou, Ben-Zhan Zhu^⁎（通讯作者）, Mechanism of synergistic DNA damage induced by the hydroquinone metabolite of brominated phenolic environmental pollutants and Cu(II): Formation of DNA-Cu complex and site-specific production of hydroxyl radicals, Free Radical Biology and Medicine, 2017, 104. 54-63.

6、Jie Shao, Chun-Hua Huang, Bo Shao, Li Qin, Dan Xu, Feng Li, Na Qu, Lin-Na Xie, Balaraman Kalyanaraman, Ben-Zhan Zhu（通讯作者）, Potent Oxidation of DNA by Haloquinoid Disinfection Byproducts to the More Mutagenic Imidazolone dIz via an Unprecedented Haloquinone-Enoxy Radical-Mediated Mechanism, Environ Sci Technol, 2020, 54(10):6244-6253.

7、Chun-Hua Huang, Miao Tang, Dan Xu, Bo Shao, Pei-Lin Li, Tian-Shu Tang, Li Qin, Ben-Zhan Zhu（通讯作者）, The critical role of unique azido-substituted chloro-O-semiquinone radical intermediates in the synergistic toxicity between sodium azide and chlorocatecholic carcinogens, Free Radic Biol Med, 2021, 177:260-269.

8、Hui-Ying Gao, Chun-Hua Huang, Li Mao, Bo Shao, Jie Shao, Zhu-Ying Yan, Miao Tang, Ben-Zhan Zhu（通讯作者）, First Direct and Unequivocal Electron Spin Resonance Spin-Trapping Evidence for pH-Dependent Production of Hydroxyl Radicals from Sulfate Radicals, Environ Sci Technol, 2020, 54(21):14046-14056

9、Li Mao, Chun-Hua Huang, Bo Shao, Li Qin, Miao Tang, Zhu-Ying Yan, Zhi-Sheng Liu, Jie Shao, Zhi-Guo Sheng, Ben-Zhan Zhu（通讯作者）, The critical role of superoxide anion radicals on delaying tetrachlorohydroquinone autooxidation by penicillamine, Free Radic Biol Med, 2021, 163:369-378.

10、Li Qin, Chun-Hua Huang, Li Mao, Bo Shao, Ben-Zhan Zhu（通讯作者）, First unequivocal identification of the critical acyl radicals from the anti-tuberculosis drug isoniazid and its hydrazide analogs by complementary applications of ESR spin-trapping and HPLC/MS methods, Free Radic Biol Med, 2020, 154:1-8.